They shared several similarities with SARS-CoV-2 IGRA-negative patients in demographic characteristics, comorbidity burden, and TrimericS-IgG and N-IgG antibody responses, although they exhibited higher T cell and CD4+ T cell counts, higher ferritin and IL-6 levels, with the latter showing the highest numerical values observed among the groups, and higher frequency of prior COVID-19 (Table 1). This evidence concerns the gene CD4 and COVID-19.