Indeed, although Tg value is influenced by several factors (i.e. residual thyroid cancer and/or normal thyroid tissue, TSH level, functional sensitivity of the assay, iodine status, etc.)other studies confirmed its predictive role for persistence/recurrence of disease (33, 34, 35, 36, 37, 38, 39). This evidence concerns the gene TG and thyroid gland carcinoma.