Although enhanced oxidative stress and subsequent induction of senescence via the p53/p21 pathway has been previously found in Sim-treated human melanoma cells (Guterres et al., 2013), it should be noted that Sim has also been described as an antioxidative and chondroprotective drug in cartilage (Riegger et al., 2022). This evidence concerns the gene TP53 and melanoma.