While measurements of key insulin signaling intermediaries (AKT2, PI3K-p85α, mTOR, p44/42 MAPK, SAPK/JNK) do not indicate any changes in hepatic insulin receptor function in 3 month CBD-exposed male offspring, the decrease in hepatic Glut2 protein levels indicates that the liver may be one peripheral contributor to the glucose intolerance observed (Seyer et al. 2013, Thorens 2015). This evidence concerns the gene INSR and Glucose intolerance.