We interpreted these data in two possible ways: (i) Enhanced hepatic insulin signaling preceding a metabolic challenge may protect the male mTORKOpl offspring from insulin resistance when subjected to the metabolic challenge of an HFD, as seen in Akhaphong et al. (Akhaphong et al. 2021); (ii) The increase in hepatic insulin signaling may be reflective of underlying dysfunction. Here, INS is linked to Insulin resistance.