Given that age is a risk for AD and that GC and sex steroid levels are inversely regulated (increased and decreased, respectively) during aging [136], future studies should further clarify the molecular underpinning of the complex interplay between sex, aging and stress in the precipitation of AD, as well as further dissect the GC and CRF contribution to the stress-driven AD brain pathology. The gene discussed is CRH; the disease is Alzheimer disease.