Along with this line, IL‐27ra−/− mice exhibited exacerbated Th1‐mediated immune response in an acute model of P. berghei infection and were susceptible to infection due to liver pathology despite efficient parasite clearance, indicating that IL‐27 regulates Th1 response during acute infection (Findlay et al, 2010; Villegas‐Mendez et al, 2013). The gene discussed is IL27; the disease is infection.