To uncover the responding CD4+ T cell subsets at the transcriptional level, we performed single‐cell RNA‐seq (scRNA‐seq) and compared PbT‐II cells from anti‐IL‐27 mAb‐ and control IgG‐treated mice on day 7 and 28 after infection (Figs 4, 5 and EV3). Here, CD4 is linked to infection.