It is thought that early-onset CRC has an MSI expression from the methylated MLH1 gene that is responsible for controlling DNA replication, which is also controlled by other genes, such as MSH2 and MSH6. This process led to mutations in the BRAF gene, and the BRAF V600E mutation is widely accepted as a prognostic factor of sporadic CRC with MSI [35]. Here, BRAF is linked to colorectal carcinoma.