Bethel et al. showed a significant decrease in MACE (HR 0.90, 95% CI 0.82-0.99; p=0.033) and all-cause mortality (0.88, 0.81-0.95; p=0.002), but did not find any effect of GLP-1 on myocardial infarction and stroke incidence [42]. This evidence concerns the gene GCG and stroke disorder.