AKT1 and central nervous system cancer: In gynecological cancers, such as ovarian and cervical cancer, several molecular variables are linked to metastasis, including HOX genes, PI3K/AKT/mTOR signaling pathway, EGFR, platelet-derived growth factor receptors, and vascular endothelial growth factor (VEGF) (27)—for instance, the ovulatory cycle-induced angiogenesis, the presence of COX-1, and the availability of growth factors offer an ideal environment for the implantation of glioma-initiating cells (GICs) in ovarian cancer (OC).