Rescue studies as well as the luciferase reporter assay demonstrated that the downregulation of hsa-circ0026123 led to the sponging of miR-124 3p and further suppression of EZH2. They concluded that hsa-circ0026123 affected the miR-124-3p/EZH2 signaling pathway to suppress ovarian cancer, and this approach may be one of the potent bio-markers for OC and possibly a target proposed for treatment (390). This evidence concerns the gene EZH2 and ovarian cancer.