Furthermore, lnc-ATB knock-down reduced the TGFβ-induced EMT phenotype by increasing miR-126 and also decreased migration and invasion.Silencing of lnc-ATB in vivo resulted in a decreased tumor size and a lower expression of PIK3R2/Sox2 and PCNA signaling proteins and reversed the EMT phenotype in the tumor. The gene discussed is SOX2; the disease is neoplasm.