BRCA1 and ovarian cancer: Interestingly, among all the pathways activated or repressed in BRCA1-defective EOCs compared to BRCAwt cases, both the BRCA1met and BRCA1mut groups shared significant upregulation of proliferation signature (p = 0.02232 and p = 0.01051, respectively), suggesting a more aggressive behavior of these EOCs in comparison to HR proficient ovarian cancers (Table 2).