13,56 We have identified that DEFA5 can differentiate CC and UC amomg IC patients with the first clinic visit endoscopy biopsy without ambiguity or delay. Overall, significant differences in expression profiles of 546 genes identified CC and UC as distinct molecular entities and as yet unexplored pathobiologies and IBD-predisposing candidate genes. 5 The gene discussed is DEFA5; the disease is inflammatory bowel disease.