MC4R isof particular interest as a therapeutic target for obesityand metabolic disorders.31 MC4R is expressedabundantly in the central and peripheral nervous system and is a Gαs protein-coupled receptor that responds to endogenousα- and β-melanocyte-stimulating hormones and can alsosignal via β-arrestin-dependent pathways in response to agoniststimulation. Here, MC4R is linked to metabolic disease.