CDH1 and cancer: On the otherhand, epithelial-mesenchymal transition (EMT) plays a critical rolein cancer invasion and metastasis and it is known to contribute toEGFR-TKI resistance.18 HDACIs have beenreported to reverse EMT by upregulating E-cadherin.19 In H1975 cells, flunarizine was found to upregulate E-cadherinbut downregulate vimentin expression in a concentration-dependentmanner (Figure 6B),presumably leading to the inhibition of cancer cell migration (Figure 6C) and invasion (Figure 6D).