The tumor specimen was found to carry EGFR mutations L858Rand T790 M. Compared with the control mice at termination of the experiment(day 32), tumor volume was found to be 535 ± 124, 834 ±143, 285 ± 68, 368 ± 101, and 226 ± 33 mm2 for gefitinib alone, flunarizine alone, gefitinib + flunarizinecombination, SAHA alone, and gefitinib + SAHA combination, respectively(vs 1108 ± 223 mm2 for the control mice). This evidence concerns the gene EGFR and neoplasm.