HDAC9 and non-small cell lung carcinoma: In this study, apart fromacetylated histone H3 (class I HDAC substrate), the protein acetylationlevel of a representative class II HDAC substrate (α-tubulin)was also examined in NSCLC cells after incubation with the HDACI candidates.In agreement with the known inhibition of both class I and II HDACsby SAHA, the level of acetylation of histone H3 and α-tubulinwas increased by SAHA in a concentration-dependent manner (Figure 1C).