Certain matrix metalloproteinases(MMPs) mediate cancer progression,with a number of ECM components controlling their expression and activity.53 MMP-14 is one of the essential MMPs expressedby the invasive TNBC cell lines, MDA-MB-231 and MDA-MB-436.54 In addition, the cross-talk between MMP-14 andCD44 is an essential step towards activating of cancer cell migration.55 Hence, the inhibition of MMP-14/CD44 hetero-dimerizationwas suggested as an efficient way to inhibit the MMP-14-mediated cancercell migration. The gene discussed is CD44; the disease is cancer.