Sigma1Rs are another targetof tryptamines that can modulate epileptiformactivity.11,57−59 Also, fenfluramine wasshown to act as a positive allosteric modulator at sigma1Rs in miceand zebrafish models,60 and sigma1R modulationprevents seizures in models of Dravet syndrome, amphetamine-inducedseizures, and epileptic encephalopathies.59,61,62 We tested the hypothesis that the serotonergicpsychedelic N,N-dipropyltryptamine (DPT) would preventAGS in juvenile Fmr1 KO mice and that it would beeffective via a serotonergic or sigma1R mechanism. Here, SIGMAR1 is linked to encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.