At the early stage of viral infection, the immune system promotes the production of pro-inflammatory cytokines such as IFN-α, IFN-β, TNF-α, IL-6 and promotes the production of anti-inflammatory cytokines to maintain homeostasis and prevent tissue damage caused by constantly excessive inflammatory cytokines known as a cytokine storm at the late stage of infection. The gene discussed is IFNB1; the disease is viral infectious disease.