Further phenotypical and functional analysis showed that circulating γδ T cells in relapsing-remitting multiple sclerosis (RRMS) patients have a reduction in the circulating CCR5+ γδ T-cell subset with decreased EOMES and granzyme B mRNA abundance and increased production of IFN-γ (129). This evidence concerns the gene GZMB and relapsing-remitting multiple sclerosis.