IGFBP1 and preeclampsia: Among these, there was a significant overrepresentation of the EVT2 subtype in PE samples compared to controls, and these cells exhibited relatively high expression of genes associated with inflammatory fibrosis, such as MALAT1, IGFBP1, CD74, RNASE1, and SPP1. These findings were partly supported by a single cell-seq of decidual tissue of the placental bed that, SPP1 was found up-regulated in EVTs of late-onset preeclampsia (40).