In addition, CC-11050 treatment significantly downregulated the expression of genes that play a key role in lung fibrosis, such as TGFB1 (16 dpi; p=0.0433), COL1A1 (16 dpi, p=0.009), TAGLN (16 dpi; p=0.0218), MYH11 (4 dpi; p=0.0042; 16 dpi; p=0.05) and SMAD2 (16 dpi; p=0.008) (Figure 6A). This evidence concerns the gene COL1A1 and pulmonary fibrosis.