NLRP3 and Muckle-Wells syndrome: NLRP3 gene is responsible for encoding cryopyrin protein, and its mutations commonly lead to three distinct periodic fever syndromes with varying severity: FCAS (OMIM 120100), Muckle-Wells syndrome (MWS) (OMIM 191900), as well as chronic infantile neurologic cutaneous articular syndrome (CINCA) (OMIM 607115) (5).