Recently, three type I IFN response markers, namely human MX Dynamin Like GTPase 1 (MX1), double-stranded RNA sensor protein kinase R, and HLA class I, were found to be expressed in a significantly higher percentage of insulin-containing islets from autoantibody-positive and/or recent-onset type 1 diabetes donors (10). This evidence concerns the gene MX1 and type 1 diabetes mellitus.