Similar to ferritin, most grades 3 and 4 CRS (median 59.4; range 1.2 to 960) and 0 to 2 CRS (median 8.535; the peak CRP of patients ranged from 0.818 to 288) were very high, and the CRS in grades 3 and was significantly (P < 0.001) different from that in grades 0 to 2. This evidence concerns the gene CRP and congenital rubella syndrome.