For example, many of the most high-risk disease loci for EoE encode epithelial proteins including calpain 14, thymic stromal lymphopoietin (TSLP), Desmoglein 1, Filaggrin, and STAT6 (12, 17–20—all) of which have been shown to be relevant to epithelial barrier integrity and/or T2 inflammation (2, 21). This evidence concerns the gene TSLP and eosinophilic esophagitis.