Endothelial dysfunction, oxidative stress and inflammation associated with hypertension induced by Ang-II or DOCA/salt, are prevented in models deficient in macrophage colony stimulating factor (M-CSF or CSF-1) inducing decrease of monocyte/macrophage cell profile (De Ciuceis et al., 2005; Ko et al., 2007). Here, CSF1 is linked to hypertensive disorder.