This loop includes ACE/ACE-2/Ang 1–7/Ang 1–9 as protective mediators serving to counterbalance the pro-inflammatory effects of activated RAS and ameliorating vascular damage and arterial hypertension, induced (Mendoza-Torres et al., 2018) mainly via prevention of oxidative stress and downregulation of IL-6, IL-1β, MCP-1, and TNF-α released mostly by monocytes/macrophage (Cha et al., 2018). Here, ACE is linked to Hypertension.