Monocyte/macrophage express ATR (Hahn et al., 1994), angiotensinogen (Gomez et al., 1993), renin (Iwai et al., 1996), as well as angiotensin peptide hormone (Dezso et al., 1989) thus, monocyte/macrophage activity and function is modulated by RAS components during hypertension. This evidence concerns the gene AGT and hypertensive disorder.