Nevertheless, the signaling pathways by which angiotensin-II interacts with the monocyte/macrophage cells during hypertension and the specific role of ACE and ACE-2 remain unrevealed, hence more studies are necessary to clarify the mechanisms of Ang-II activating monocyte-macrophage cells during hypertension, and to highlight potential target treatments. The gene discussed is ACE; the disease is hypertensive disorder.