AGT and Hypertension: Furthermore, Wenzel et al., 2015 (Wenzel et al., 2015) reported that heme oxygenase-1 (HO-1) which is a modulator of endothelial function in Ang-II-induced hypertension and vascular diseases suppresses the pro-inflammatory phenotype of monocytes/macrophages and controls their function in Ang-II induced hypertension animal model and human.