Similar to WT STm infection, genes involved in the regulation of immune responses (ATF3, BATF3, ETS2, IRF9, NFκB2, MAFA, TNFAIP3), effector functions, (CCL4, CD200L, CD40, CD72, CD80, IL18) and TLR signaling, (EAF2, TLR15, TRAF3IP2, TOLLIP) were upregulated after ΔprgH STm infection in both models (Supplementary Material 2). Here, CD40 is linked to infection.