To elucidate the roles of HK2 in the progression of DLBCL, the human normal B-cell line HMy2.CIR and the DLBCL cells TMD8, OCI-Ly3, U2932, OCI-Ly1, OCI-Ly7, SU-DHL-4, and SU-DHL-6 were used, and the expression levels of HK2 in these cells were explored with qPCR and western blotting. Here, HK2 is linked to diffuse large B-cell lymphoma.