The etiology of osteoarthritis remains incompletely understood, but various molecular mechanisms have been shown to be involved in this pathological process, including the JAK/STAT signaling pathway [54], PI3K/AKT/mTOR signaling pathway [55,56], p38 MAPK/c-Fos/AP-1 pathway [57], and Wnt/β-linked protein pathway [58]. This evidence concerns the gene FOS and osteoarthritis.