MSH2 and colorectal carcinoma: To determine whether carrying P/LP variants in these genes confer an increased risk of CRC in the Chinese population, we performed a control-based risk analysis, which indicates that P/LP variants in the MMR pathway genes, MLH1, MSH2, APC, MSH6, TP53, and PMS2, were associated with an increased risk for CRC, consistent with what was known previously for LS [17–19].