Hence, we should also take into consideration whether the population that shows an increase in serum vitamin D concentrations due to meat consumption may obscure the health effects of vitamin D. The mechanism by which 25(OH)D reduces the risk of mortality from cardiovascular disease may involve the inhibition of renin synthesis, reduction of angiotensin II production, improvement of pancreatic beta-cell function, endothelial protective effects, and immunomodulatory activities, as suggested by previous research (18). The gene discussed is REN; the disease is cardiovascular disorder.