PRKDC and colon adenocarcinoma: Besides, the mutation frequencies of PRKDC in malignancies were dramaticly high, with over 10% of whole tested in uterine corpus endometrial carcinoma (UCEC, 16.57%), skin cutaneous melanoma (SKCM,13.24%), and colon adenocarcinoma (COAD, 10.10%) (Supplementary Figure 3C).