WNT2 and preeclampsia: Furthermore, BPA-exposed mice exhibited preeclampsia-like features, including hypertension, disrupted angiogenesis biomarkers in circulation, and placenta’s involvement in the reprogramming of DNA methylation of WNT2/beta-catenin gene, indicating that exposure window of placental development is the most critical for the epigenetic targets, thereby, a key determinant for the progression of placental-disease preeclampsia (272).