TGFB1 and hypothyroidism: Additionally, the high expression of TGF-β1 was significantly related to hypothyroidism (50.0% vs. 75.8%, P = 0.03), GH deficiency (23.7% vs. 54,5%, P = 0.014), and DI (10.5% vs. 42.4%, P = 0.003) (Figure 4B).