Thyroglobulin (Tg) is a 660-kDa molecular weight glycoprotein synthesized by thyrocytes and released into the thyroid follicular lumen.1Tg production is stimulated by intrathyroidal iodine deficiency or excess, thyroid-stimulating hormone (TSH), and the presence of thyroid-stimulating immunoglobulins.2Several studies have investigated the role of preoperative serum Tg values as a predictor of malignancy in thyroid nodules. The gene discussed is TG; the disease is thyroid nodule.