SIX1 and branchio-oto-renal syndrome: Our long-standing interest in this quest has been to reveal the molecular interactions between the Six1 transcription factor and putative interacting partners that may account for variable craniofacial malformations found in Branchio-oto-renal syndrome (BOR) patients that include: the outer, middle, and inner ear; branchial fistulas and cysts; and in some cases renal abnormalities (Moody et al., 2015; Smith, 2018).