HIPK2 and neoplasm: Aside from important roles in development, dysregulation of HIPK2 is associated with tumour suppression or tumourigenesis depending on the cellular context, as HIPK2 has been shown to bind to a wide variety of transcription factors and cofactors and therefore can modulate their effects through various signalling pathways (Puca et al., 2010; Conte et al., 2023).