SLURP1 and central nervous system cancer: For example, human SLURP-1, a selective negative allosteric modulator of α7-nAChR (Lyukmanova et al., 2016), inhibits growth of different carcinoma and glioma cells in vitro in 2D and 3D tumor models (Lyukmanova et al., 2014; 2018; Throm et al., 2018; Bychkov et al., 2019; 2021; Shulepko et al., 2020a; 2023) and abolishes the nicotine-induced cell proliferation (Shulepko et al., 2020b).