SLURP-1 increased phosphorylation of the transcription factors STAT5a/b (Y694/Y699), probably, activating them, but decreased phosphorylation of CREB (S133), STAT2 (Y689), STAT3 (Y705), and STAT6 (Y641), which are important for tumor progression and regulation of tumor inflammatory microenvironment (Loh et al., 2019) (Figure 2). This evidence concerns the gene STAT3 and neoplasm.