Other studies implicated IL-11 with the onset and progression of fibrotic diseases (Schafer et al., 2017; Widjaja et al., 2019), autoimmune diseases (Hermann et al., 1998; Figueiredo et al., 2014; Adami et al., 2021), Alzheimer’s disease (Galimberti et al., 2008; Pellicanò et al., 2009) and various types of cancer diseases (Lay et al., 2012; Putoczki et al., 2013; Liang et al., 2019). Here, IL11 is linked to early-onset autosomal dominant Alzheimer disease.