E2F2 and hepatocellular carcinoma: Hu et al. (2022) established an E2F target gene signature composed of five genes (HN1, KIF4A, CDCA3, CDCA8, and SSRP1) and found it is significantly related to the prognosis of hepatocellular carcinoma. Two-E2F (E2F2 and E2F5) prognostic signature was built by Wang et al. (2023), and they estimated immune infiltration levels for patients in different risk groups.