Furthermore, several lines of evidence supported that Malassezia may directly contribute to PD: (1) many PD risk alleles affect the metabolism of lipids, (2) the invasiveness of Malassezia is stimulated by L-DOPA, and (3) low CD4 + T cell counts observed in PD might lead to the over-proliferation of Malassezia (Laurence et al., 2019). The gene discussed is CD4; the disease is Parkinson disease.