CDK4 and cancer: To investigate the possibility of differential expression of secretome and ligands associated with pro‐tumorigenic immune modulation by DNA‐damaging agent‐ and CDK4/6i‐induced senescent cancer cells, we performed GSEA using gene sets related to IL‐6, TNFα, cytokines, and inflammation and showed that enrichment score (ES) of gene sets was significantly higher in the DNA‐damaging agent‐ than in the CDK4/6i‐induced senescent cells (Fig. 3A and Fig. S2A).