The heatmap for genes involved in activating anti‐tumor immune responses showed increased expression of T‐cell chemokines (CXCL9, CXCL10, and CXCL11) [48, 49, 50, 51, 52], antigen processing proteins (TAP1, TAP2, TAPBP, ERAP1, and ERAP2) [44, 45, 53, 54, 55, 56], and MHC class I molecules (HLAs and B2M) in both DNA‐damaging agent‐ and CDK4/6i‐induced senescent cells, indicating activation of anti‐tumor immunity in both the groups (Fig. 5D). Here, CDK4 is linked to neoplasm.