In the present study, although the extent of senescence elicited by DNA‐damaging agents and CDK4/6i was similar, CDK4/6i‐induced senescent cancer cells showed significantly lower expression of well‐known pro‐inflammatory SASP such as IL‐6, CXCL1, CXCL8, and TGF‐β. This evidence concerns the gene CDK4 and cancer.