CDK4 and cancer: In addition, senescent cancer cells by other types of DNA damaging agents (Etoposide and Carboplatin) (Fig. S4A,B) and CDK4/6i (Abemaciclib) also showed similar trends of mRNA expression pattern in pro‐inflammatory SASP (Fig. S4C), pro‐angiogenic factors (Fig. S4D), and anti‐tumor immune‐related genes (Fig. S4F).