ADAMTS4 and aortic aneurysm: Kaufmann et al42 introduced a new MR probe that targets ADAMTS4 (a disintegrin and metalloproteinase with thrombospondin motifs 4) which can break down ECM and is involved in aortic aneurysm formation and rupture.66 This MR probe was validated in vivo in a murine model involving cross-sectional and longitudinal parts, as well as ex vivo in excised human aortic tissue.