Interestingly, among of BRAF wild type (WT) and mutation, TCGA (The Cancer Genome Atlas) and GEO (Gene Expression Omnibus) of CRC tissue specimens exhibited strikingly distinct infiltration pattern of diverse immune subsets within the TIME, with higher expression of immunoinhibitory molecules (PD-1, PD-L1, CTLA-4, LAG-3, and TIM3), enhanced immune cell infiltration (neutrophils and macrophages M1) and less tumor component in BRAF mutant tumors [7]. The gene discussed is BRAF; the disease is colorectal carcinoma.