Tumor promoting inflammation was recognized as a hallmark of cancer in 2011 [122], and the critical involvement of smoldering inflammation in carcinogenesis has been increasingly acknowledged since then Phenotypic plasticity was added to the list of hallmarks in 2022 [123] and involvement of major inflammatory pathway—NF-κB signaling—in regulation of phenotype plasticity has been now widely recognized. Here, NFKB1 is linked to cancer.