ZEB1 and neoplasm: Cheng et al. [31] determined the status of EMT transcription factors Twist, Zeb1, and Zeb2 alongside Snail as they investigated the previously established association of tumor hypoxia, the expression of hypoxia-inducible factor-1 (HIF-1) and the constitutive activation of NF-κB with the development of pancreatic cancer (PC).