PDPN and metastatic malignant neoplasm: Metastatic cancer-1 cells highly expressed mesenchymal markers (e.g., VIM, FN1, and COL1A1), typical of EMT, whereas metastatic cancer-2 cells highly expressed partial EMT (p-EMT) signature genes (e.g., LAMC2, PDPN, and INHBA) [9], indicative of a p-EMT phenotype.