Keratinocyte cancer cells highly expressed epithelial differentiation marker genes (SPRR3 and SPRR2A), while migratory proliferative (migraproliferative) cancer cells highly expressed malignancy-promoting factors MARCKSL1, RPL39L, ANXA3, and HMGB1. We identified two subsets with different epithelial-mesenchymal transition (EMT) characteristics. This evidence concerns the gene HMGB1 and cancer.