Formerly, the full length RIZ1 was extensively investigated in several cancers where it acts as a tumor suppressor, whereas few studies had explored the oncogenic properties of RIZ2. Recently, we showed that RIZ2 overexpression increased cell viability and growth, prompted the G2-to-M phase transition and organoids formation in HEK293 cells [5, 6]. Here, PRDM2 is linked to cancer.