Additionally, DLD1 RIZ2 overexpressing cells showed a higher ability to reduce the wounded areas in wound scratch assays and invade collagen or Matrigel thick layers more efficiently than DLD1 control cells, suggesting a role for RIZ isoform imbalance in regulating colon cancer cell migration and invasion (Fig. 2). This evidence concerns the gene PRDM2 and malignant colon neoplasm.