CD8A and neoplasm: We observed that the HR group exhibited upregulated activity in most steps of the tumor immune cycle, including the release of cancer cell antigens (step 1), the presentation of cancer antigens (step 2), priming and activation (step 3), and the entry of immune cells into the tumor (step 4), such as T cell recruitment, CD8 T cell recruitment, Th1 recruitment, DC cell recruitment, and Th22 cell recruitment (Fig. 10F).