However, the TB patients had significantly lower proportions of B cells, CD4 + memory T cells, CD4 + naive T cells, CD4 + T cells, CD4 + Tcm, CD4 + Tem, CD8 + T cells, CD8 + Tcm, CD8 + Tem, cDC, class-switched memory B cells, iDC, mast cells, memory B cells, naive B cells, NK cells, pro B cells, and Th1 cells compared to the HC (Fig. 6A). This evidence concerns the gene CD8A and tuberculosis.