TNF and immune system disorder: GSEA results indicated that these DEGs were primarily enriched in immune-inflammatory pathways, such as immune response to tuberculosis, interferon alpha beta signaling, interleukin 15 signaling, diseases of immune system, pyroptosis, interferon gamma signaling, IL6 siganling pathway, neutrophil degranulation, interleukin 10 signaling, toll like receptor cascades, TNF signaling, interleukin 1 family signaling, apoptosis, JAK-STAT singaling pathway, chemokine signaling pathway, IL18 signaling pathway, etc. (Fig. 7C).