Additionally, lung biopsies from patients with severe COVID-19 exhibit downregulation of NRF2-mediated gene expression [34], and in vitro and in vivo studies have indicated that SARS-CoV-2 infection inhibits GSH and increases its oxidative form, GSSG, leading to reduced NRF2 activity [33, 35]. This evidence concerns the gene NFE2L2 and COVID-19.