These data are further validated by evidence that Influenza virus PR/8 infection of cultured HEK-293T cells results in a transcriptional downregulation of NRF2 at early times of infection (24 h), leading to a decrease (fold expression 0.21 ± 0.03; p = 0.006) in specific mRNA content, as previously demonstrated in literature [30] (Fig. 3A). This evidence concerns the gene NFE2L2 and infection.