A comprehensive bioinformatics analysis of endometrial cancer revealed 4 differential genes related to survival: BUB1, BUB1B, CCNA2, and CDCA8. Immunohistochemical experiments on tissues from 29 patients with uterine fibroids and 50 patients with EC were performed to confirm these findings. Here, CDCA8 is linked to uterine corpus leiomyoma.